Shiseido's sodium hyaluronate is not produced by extraction from animal sources. The production is based on the original fermentation technology with Streptococcus zooepidemicus, one of the naturally occurring lactic bacteria, and it does not involve any recombinant process.

Akasaka H.et al.,J. Soc. Cosmet. Chem., 22, 35 (1988)

Culture media

Culture media used for the production are glucose and peptone from plants.