Shiseido began the production of sodium hyaluronate in 1985. The production is based on fermentation with Streptococcus zooepidemicus, a bacterium, and does not involve extraction from animal organs, such as cockscomb or umbilical cords. Being approved as a cosmetic ingredient to be used for "ELIXIR Essence" on October, 1984, sodium hyaluronate has been formulated in many of Shiseido's products as a moisturizer. It also has received high evaluations from many companies of all over the world that use it for their products.
| 1985 | Formulation in Shiseido's cosmetic products |
|---|---|
| 1986 | Sales as a cosmetic ingredient |
| 1993 | Formulation in Shiseido's pharmaceutical products |
| 1998 | Sales as a pharmaceutical ingredient |
| 2003 | Sales as a food additive |
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