Highly hydrophobic acetyl groups of sodium acetyl hyaluronate are able to have a firm interaction with sebum-covered skin surface. The acetyl groups can "anchor" the whole molecule to the skin, even when it absorbs a large amount of water, using its hydrophilic backbone. The formation of the anchored structure leads to a remarkable corneum softening effect.

Mechanism of corneum softening

Sodium acetyl hyaluronate, possessing both hydrophobic and hydrophilic moieties, shows a strong affinity to stratum corneum. Water molecules released from the inside of stratum corneum are recaptured by the compound and stay on the skin, which is thought to be the mechanism of the long-lasting corneum softening effect.

