Shiseido has been making efforts to identify the cause of wrinkles and sagging of the skin associated with aging by various approaches.
Hyaluronic acid is known to help in maintenance of the skin moisture. Shiseido's study showed that "vitamin A" promoted the synthesis of hyaluronic acid and reduced wrinkles in humans. Based on theses findings, we keep trying to elucidate the mechanism of wrinkle improvement and exploring active ingredients with further efficacies. Shiseido is also investigating the network structure of collagen fibers and elastin fibers in the dermis. Active ingredients to inhibit gelatinase are under development focusing on the fact that wrinkles can be prevented by inhibiting gelatinase, an enzyme that changes the network structure.
Gelatinase:
An enzyme in the skin that degrades fibrillary elements such as collagen and elastin which confer firmness and elasticity to the skin
Wrinkle-inducing angiogenesis
Shiseido identified a new mechanism in which inflammatory cells releasing the enzyme "elastase" that damages the elastin fibers of the dermis are transferred to the skin through blood vessels generated after exposure to UV rays, the so-called "wrinkle-inducing angiogenesis" to cause wrinkles, and developed "chlorella extract," a drug to suppress the "wrinkle-inducing angiogenesis".
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