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[Cosmetics Support Technology Development] UV Protection

Development of a novel sun care product that prevents UV-induced damage from within the skin We achieved UV protection with the protein "metallothionein ".

Development of novel sun care products is proceeding. These products not only protect the skin from UV rays, but prevent UV damage within the skin.

When the skin is exposed to ultraviolet light, reactive oxygen species and free radicals are generated which damage cells with the resulting production of sunburn cells and injury to DNA. Repeated insults to the skin over a long period may lead to skin cancer.



"Metallothionein" has the function of counteracting reactive oxygen species, but ordinarily it is minimally produced in the skin. Shiseido discovered that metallothionein is formed inside the skin when zinc compounds, utilized as cosmetic raw material, are applied to the skin. This discovery was utilized in the preparation of sun care products.

Induction of metallothionein in a three-dimensional human skin culture model
Metallothionein was colored brown by the antibody staining technique. The picture shows metallothionein to have been induced in the skin to which a zinc compound was applied.

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